**************** The 4th., Lab Seminar ****************************

Date: Tue, June 13, 2006  PM 1:30-

Place: No.616 Seminar room
　　　　　　 Graduate School of Information Science

Speaker: Masayoshi Takayanagi 

Title: A Strand-Loop-Strand Structure Is a Possible Intermediate in 
Fibril Elongation: Long Time Simulations of Amyloid-β Peptide (10-35)
(W. Han and Y.-D. Wu, J. Am. Chem. Soc. 2005, 127, 15408)

Abstract:
 A total of 6.2 μs molecular dynamics simulations of amyloid-β (10-35)
were performed.  The results reveal that the collapsed-coil structure
determined by experiments is stable at pH 5.6, but it can exchange with a 
strand-loop-strand (SLS) structure on the microsecond time scale.
The SLS structure topologically resembles the proposed monomer conformation 
in fibrils.  We propose that the SLS structure may be an important
intermediate binding structure for amyloid-β fibril growth.

*******************************************************************