**************** The 14th., Lab Seminar *****************

Date: Mon, October 24, 2005  PM 1:30-

Place: No.616 Seminar room
　　　　　　 Graduate School of Information Science

Speaker: Hiroto Okumura

Title: A Steric Mechanism for Inhibition of CO Binding to Heme Proteins
G.S.Kachalova, A.N.Popov, H.D.Bartunik Science 284(1999) 473.

Abstract:
 The crystal structure of myoglobin in the deoxy- and carbon
monoxide-ligated states at a resolution of 1.15 angstroms show that carbon
monoxide binding at ambient temperatures requires concerted motions of the
heme, the iron, and helices E and F for relief of steric inhibition. These
steps constitute the main mechanism by which heme proteins lower the
affinity of the heme group for the toxic ligand carbon monoxide.

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