**************** The 18th., Lab Seminar *****************

Date: Thu, December 17, 2004  PM 1:00-

Place: No.616 Seminar room
　　　　　　 Graduate School of Information Science

Speaker: Youichi Jindo

Title: Modeling and simulation of the human delta opioid recepter
(Mahalaxmi Aburi and Paul E. Smith
Protein Science, 2004, 13, 1997-2008)

Abstract:
 A model for the human delta opioid receptor has been generated via sequence
alignment, as a template, and refinement by molecular dynamics simulation.
The model building suggested that, in addition to the previously postulated
interaction between D128 and Y308, an internal salt bridge also exists
between residues D128 and R192, both of which are conserved in all the
opioid receptors. The model and salt bridge were then shown to be stable
during a 20-nsec simulation in a lipid bilayer. It is therefore proposed
that both of these interactions play a role in stabilizing the inactive
state of the receptor.

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